Maybe, I'm not really sure. I do travel I-81 between Wytheville, VA and Knoxville, TN and can tell you there is usually A LOT of traffic on that section also (if you are thinking of taking I-81 to I-40 to I-75 but Knoxville can be a bear in traffic). Other than that I guess you could go I-95 to I-20. I don't know how much better that would be as I'm not familiar with that route. Don't know if this helps or not. We are taking I-77 and picking up I-85 in Charlotte. Have fun and be safe.
Foothills of NC
2012 Starcraft Autumn Ridge 309BHL
2004 F-150 4x4 Super Crew
2000 Kawasaki ZRX1100