That is a trek for a day outing.
what time of day would you be going through Baltimore?
You will have to get off 95 and go around Baltimore on the beltway (695). Either way (the west or east would be fine though going East would get another toll when you go over the Francis Scott Key bridge there). Rush hour would be very slow no matter which way you go.
There is no weight restrictions that I am aware of, but I think they have the big trucks use the ez pass only lanes located on the right end of the toll plaza. I see the trucks going through those all the time. I would just follow them if you are not sure. I have used those lanes with just my car, so they are not truck only lanes.
HTT: "EscapeII" 2016 Shamrock 23WS (current)
PUP: "Escape" 2010 Rockwood HW 277 (gone)
TV: "Bruce" 2011 Dodge Durango V8 Hemi Crew
Just us gals (me, Sis and our daughters)
Traveled 19520 miles and 209 nights in 7 years and counting