Here's my input on this truck thing for what it's worth.
I've always had Chevrolet Silverado pickup's, always liked them and puled a TT to AZ two years in a row. Mileage was bad but thought that was what I got with a gas engine. I had leased them and always turned them in with no issues. Then When my 2007 was due to be turned in I started shopping because we liked and wanted a 41 foot Cedar Creek 5th wheel and Chevy was a bit slow coming out with the 2011 model so I went and looked at the 2011 Super Duty with the 6.7 Power Stroke Diesel. What a truck it was.
We got one and drove it around home for 4000 miles and then headed for AZ with that 15,500 pound 5th wheel and what a ride it was. I've become a Ford believer now, It is comfortable and pulled that 5th wheel like it wasn't even there. We drove 2,234 and our avg mileage was 9.2 mpg. I'm told that when this diesel gets broke in it'll get better mileage pulling the 5th wheel.
If you are looking for a pickup to pull a TT or a 5th wheel check out the new Ford F250. It's a beast and you'll fine it's nicer then the Chevrolet Silverado.. Sorry GM, Ford has done their homework.
Oh I guess one of my comfort secrets is I also have the Hensley Trailer Saver 5th wheel hitch. Absolutely no jarring, It's like towing on air.
Hensley has great products.