One of my good buddies/camping friend owns a wood flooring sanding and installation company. They have a Ford E350 V10 and a Chev 3500 6.0l, both of which are loaded with sanding and stain equipment, and both vans tow his enclosed trailer for install jobs. Granted the trailer is only 18-20' and I think only has a 10,000lb GVW, but both of the vans have close to 150,000 miles with limited problems that I know of.
TT-2013 Passport 3220BH
TV-2004 F150 FX4, not exactly stock...
with 2001 Kodiak K215: 2010-10, 2011-12
with 2012 Grey Wolf 26BH: 2012-19, 2013-24, 2014-11, 2015-6
with 2013 Passport: 2015-13, 2016-15 booked