The question is too vague for anyone to answer correctly. IMO, this question is best left for your hitch/weight distribution/ball/coupler manufacturer or at the very least the installation/operation/maintenance manual for your particular product.
I have used a lot of different hitches over the years, because we formerly rented trailers. I know the Curt hitch manuals I have used say to lubricate the ball with a light coat of grease. At least, some Reese (Coquent Performance Products) hitches said to lubricate the ball but it was a small amount like a couple drops. I don't recall seeing anything about it in the Reese Dual cam, the Equal-I-zer or the E2 manuals but Reese and Progress MFG definitely both sell lube for the ball.
ever lubricate an Andersen hitch ball. That would remove your friction designed for anti-sway.
In any case, I wouldn't recommend guessing or asking the generic question on here without your actual product info.
And yes, you still have to keep it clean.
PS My dad's family home was Ennis