Speed 62-64 mph. What speed is comfortable for your truck to where your transmissions is not 'searching' for your Overdrive/lower gear when going up a small incline.
Look in your mirrors more than your windshield. Have good tow mirrors. Know what is coming up behind you and their speed and 'grouping'. Look in your 'blind spots' often and know if anything is in them for if you have to change lanes quickly. Always have an 'out' to get into if things go south.... (tire overheats and shreds itself)
Give 3-4 second distance from what is in front of you. If (when) someone cuts in front of you.... (grrr) slowly back off and regain your 3-4 second difference.
City interstates.... If you are on an interstate that has more than two lanes and you are 'passing through'..... stay in the middle or second lane over from the lane that enters or exits the interstate. People can come on and off the ramps and you do not have to get over. People can go around you on the left and you don't have to worry about speeding up or slowing down. Keep your 3-4 second distance..... remain calm and 'own' that lane that you are in.
If (and it will happen) you come up to where is seems that all interstate lanes are 'shut down' for what ever reason (accident)and creeping along (this is what 'I' do, imo) get in the most 'left' lane (if you are 'passing through) and creep along there until out of the accident zone (always follow safety personnel directions).
When changing lanes, give yourself miles and not milliseconds. You are slower and bigger than most people out there. Make sure that all of your lights, blinkers and brake lights work. You are taking a big gamble going out on the interstate if some don't.
Stop every two-three hours, even if you do not need fuel to do a walk around and check tires, heat of tires, flashers, etc. And for your own health, by getting your leg circulation going and clearing your mind and getting a drink, bathroom break etc. Plan your 'stops' if possible before you leave on your trip for the day. Know what is out on the road ahead.... rest areas, food and fuel stops. If the GPS says that the 'road trip' for that day from point 'A' to point 'B' is 8 hours... know that it will take closer to 10 hours. I have a Diesel, so I leave my truck running all day long and do not shut it off until at the stopping place for the day.
Do not get in a hurry.... if things 'seem' to go 'crazy' and getting stressful... do not speed up... slow down and relax. By pushing your TV on a hot Texas road (95-105 degrees) from 64 mph to 75 mph, and drive for over 2 hours, you WILL melt down a tire and have it explode and this will throw you back more in your timeline (plus, who knows what damage has been caused) even more.
You will get the hang of it and enjoy the interstate driving. Mirrors, distance, speed, hold your line/lane....
And never argue with the Navigator, they are your eyes and ears and should be your best friend..... (people that go on long road trips know what I mean.....)