I'm not from Wayne County, but grew up next county north (Iron) and we still camp at Clearwater Lake near Piedmont every summer. I grew up deer hunting near Annapolis, and the population of deer was fairly sparse there back then. It's better all over Mo now than it was 30-40 years ago, although down slightly this year to an EHD epidemic in 2011-2012. Wayne county usually has a good deer harvest although I think it has a lot to do with the kind of land you hunt on. Like most Eastern Ozark counties, there are some big tracts of unbroken timber, sometimes thousands of acres or more. If the acorn crop is good, the deer don't have to travel as much and you don't see them. If you hunt near fields (mostly pasture, some crop), you'll see more deer, especially in years with fewer acorns. The average size is good, and you'll see some big bucks, but not as much as you would in more agricultural areas of the state. The black bear population is getting pretty good in that general area as well.
There's a really good publication called Missouri Game & Fish that has a yearly summary of all deer populations and harvests by county. I think it usually comes out in 2 parts in spring or early summer, but you might be able to find the 2013 back issues. Sorry, but I don't have mine still.
Hope that helps- send me an email if you want more info.