Yes, it's changable, IF your physically able, AND you have/use the right tools. I'm 65 years young, and still am able to do my own tire changes. I have roadside assistance but do not want to wait hours for someone to show up, and many services will not change an inner flat on a dually.
That being said, you will need an oversize 4-way truck lug wrench, at least a 12 ton bottle jack (my own opinion), piece of 12" x 12" x 2" board to place under the jack, and a set of wheel chocks. Remember, your dealing with 6-7 tons of motor home, not your little Honda.
Your gonna bust your back using a lug wrench, but it's dooable. Personally, I carry a Lowe's electric 1/2 inch drive impact wrench, about 150.00 at Lowe's and it will pull off the tightest lug nut. If i'm on the side of the road, I'll kick on my generator and I'm set to go. Havent had to use it on my rig yet, except to try it out, but have used it several times to help other rv'ers.
Just be careful and think ahead of what your going to do.