We live in Whitehorse Yukon. A couple of years ago we took a class C motor home down the Alaska Hwy in November. Went through Alberta, all through the Western States & right down into South Texas, returning to Canada & back up the Alaska Hwy in mid January.
I found the motorhome handled very well in the snow & ice. I did have new Michelin M&S tires installed before we left. There was 6" of fresh snow (& snowing) on the road from Ft. Nelson to Watson Lake. Didn't set any speed records but it handled very well even on the steep grades in the mountains. our motorhome had a GM chassis but I did drive a truck with a E450 chassis for many years and they are good as long as it has weight in the back.
So as long as you watch the speed & have good tires you should be fine IMHO