Having driven both and sold both for 12 years....ignore everything on paper. The Chevy says it has more Horsepower than the Ford but they ran the engine RPM's way up to get that. I don't mean to over simplify it, but of course I will
Either one works just fine. In my opinion the difference is too slight to feel strongly either way.
The Chevy is 6" longer than the Ford and is a V8 versus Ford V10. So there is less dog house coming into the cab area, which makes it appear that there is more leg room in the Chevy. People complain about the passenger leg room in the Ford because the dog house is offset to that side so it looks tight. But frankly I'm 5'11" and have sat in the passenger side for long stretches. I've never had an issue. My wife is about 5'3" and her feet don't even make it far enough for the dog house to be an issue. The Chevy "center console" does not protrude into the cab area as far as the Ford...but the Ford is removable.
There are only two times that I would recommend one over the other.
Towing: If you do a lot of towing and intent to tow more than 5,000lbs. Go Ford.
2250: I would typically go Chevy. On this floor plan we use the big Chevy (14,200 lbs) and the E350 Ford (12,500 lbs). We still use the V10 but you don't get the 7,500 lbs hitch.
I think the Chevy rides a bit better straight from the factory (softer) but the Ford rides better when loaded (probably because of the higher torque).
So there you have it. Clear as mud. Pick either and you're absolutely right.
(The mercedes Sprinter actually has the best cabin comfort...but you're limited to 24')