My wife creates vinyl designs and presses them onto fabric from the RV. We don't do shows/fairs or anything. She has done all of her business through Facebook and we're working on a website for her. She doesn't want it to feel like work and is happy with the little scraps here or there that she gets.
I work from "home" doing programming work. Means I sit with my laptop for 8-10 hours a day. Again, not what you're asking.
I do know one family who does just what you're asking- they make soaps and jerkey and something else. I forget what it was. Apparently it does well enough that that's how they fulltime.