We cool ours down for a day before we leave, turn it off and go. We pack a cooler ( use it for drinks outside for the kids anyway ).
I tried running with it on once, the pilot blew out while running down the high way and found out when I went to set up at the campground.
Since I travel with my wife and kids, the risk just isn't worth the convenience. The fridge is the first thing I start when setting up and starts to cool down by the time I'm finished setting up.
If you ask my wife I'm overly cautious on everything.
Working in aerospace for decades has taught me to question all possibilities of failure you can think of. Murphy must have been an engineer.