I have driven with a loaded pickup and SUV from DC area to western IL a few times, but not with anything in tow. Traveled I-70, I-76 and I-80. Never had any issues and only a few long grades that I recall.
You may be using I-40/I-70 or I-64/I-71 and I'm not familiar with those routes, but there will always be a few mountain grades to go up/down on most cross country highways. I would think you would be fine, especially under 65mph. The headwinds and crosswinds will be the challange for anyone towing a brick like our trailers...lol.
TV: '15 Ram 6.4 Hemi CC 4x4
Old TT: '12 Rockwood Roo 19 (sold)
New TT: '14 CR Sunset Trail 290QB
WD: Equalizer 1200/12K
BC: Ram OEM