When you consider the forces on any unit as it travels down the highway, the best direction to place your unit in windy conditions, is head on.....as long as service connections and space allow.
If you see Toto fly by.....it doesn’t matter what direction.
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Ken and Terry
2018 Sunseeker 2430S-CD, nicely modified and carried by a 2017 Ford E450 Sport
Former Georgetown 330TS owner for 10 years with more mods than I can count, pushed by our 2017 GMC Terrain