There are pros and cons to each, ultimately it's up to the individual.
Fifth wheels tow better, have more/better storage, are generally considered better layouts.
Travel trailers can tow as well as a 5er with the right hitch (So I've read) have no interior steps, are shorter meaning access to compromised height campgrounds. You have full use of your truck bed, the one thing that is really bothering me about having a fifth wheel, I can't carry my motorcycle with me.
Personally, my 5er is a better experience all around, motorcycle aside. The storage is awesome, I love the layout, tows like a dream, I get better MPG, the floor plan is great.
Fifth wheels have one handicap, an equal size and weight 5er needs more truck to tow it than a TT does because of the pin weight. You need a higher payload rated truck to carry the 22% pin weight compared to the 15% of a TT. Nowadays that's not a big issue as trucks now have pretty healthy payload ratings but if you're using an older TV or have a half ton it's something to consider.
Now-2014 Sierra 346RETS 5er BUB
Then-2002 Keystone Springdale 286RLDS TT
Nights camped in 2014-28, 2015-127, 2016-10