Yes you can jack up one side and remove both wheels. Since you should jack on the frame and not the axles anyway, just place the jack between the wheels and jack on the frame.
You don't need to be hooked to the tow vehicle, but you need to be sure the other side is chocked well.
Having said that, it would be safer if it was hooked to the TV while the wheels were off.
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Salem 29RKSS Pushing a GMC Sierra 2500HD!
Gotta go campin!
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