Yes, have removed several, getting to water leaks and other stuff. They are a pain, but basically just bolted on. Nice to have help, and they overlap, just like a Tin roof, so must come off in order, and go back that way. Also they are sealed to the frame with expanding foam, so you will want to have some on hand when you put them back up.
Tip, take a Sharpie marker, and label them, position and draw an arrow to the front.
2012 Ford F250 ext. Cab 4x4
2002 Jeep Wrangler Sahara
2008 Yamaha V-Star 650 Classic
2008 Work and Play 18LT