I am towing an 2016 F150 4x4 with my setup. Towed it 6000 miles from Florida, montana, utah, idaho, texas, through the plains and 10K foot up.
Towed great, no problems what so ever except when I forgot to disengage the emergency brake on the f150 and remember a few miles later.
F150 4x4 can be towed all 4 down and does not accumulate miles.
I have the 2016 Fr3 32 ds
Added a Safety Plus (But should have used the Blue OX TruCenter - When towing wants to pull to the left a little adjusting from inside the cabin would have been nice)
F150 comes in at 4950 lbs. I keep the gas down to 1/8 tank to keep weight down. I had 6 people in my RV, Food for 2 month trip and was still 1500+ lbs under GCVWR.