Depends how far out of level you are. A lot of people (especially those with multiple slides) tend to block up the one side a bit more so that they're level after they put their slides out.
If you're close enough to not notice it without using a level, I wouldn't worry. If it feels like you're falling out of bed, and your drinks are sliding across your dinette, then block it up.
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There's no use crying over spilled milk, unless it's on your keyboard.