When you say "set up", is that with electric hookups or not?
If dry camping or boondocking, turning off the battery means no power to the lights, water pump, fridge/freezer, water heater, radio, fans and so on.
If hooked to electric, turning off battery may result in it not being recharged by the converter.
And as Jim said, some things may require an active battery, even when hooked to power.
and Zoe the Wonder Dog(R.I.P.)
'07 Roo 23SS pushing an '07 Chevy Avalanche
Equalizer WDH and Prodigy BC