The arguments about N2 in tires has been raging for a long time. You don't have to fill as often, some (Including me) feel it rides better afterwards. I worked at a dealer that had N2 and a machine that would purge it to 95-98% N2, I experienced no pressure fluctuation under normal conditions, but did see a two PSI change from summer to winter.
I'm a fan. Is it worth paying for it? Nope, not really. If you have a place local that doesn't mind keeping you topped up, go for it. You can find N2 bottles for tire fill like racers use, I saw one on ebay for $75, tank, regulator and gauge, I got outbid in the final seconds.
But the benefits really are more convenience. It doesn't get you more MPG, it just keeps pressure longer. Tire rot and wheel corrosion from moisture inside the tire is rare today, but not unheard of. I personally feel it rides better, but it is still a truck.
I feel it's like many advances that came from aerospace. I think it'll be the norm in a decade or so, to the point that N2 will be readily available most everywhere like compressed air is at gas stations. Just like disc brakes, drums do work fine, and discs were an option many saw as unnecessary to pay for. Then they became standard. Now disc brakes are unquestionably superior to drums, I'm not saying N2 is the same at all, but I think the mindset will follow suit. Eventually N2 will just become normal.
I'll tell you this, if the manufacturers start putting N2 in cars and trucks from the factory you'll see it literally take off like wildfire. And I'll guarantee the compressed gas lobby has been knocking on doors in Detroit, Japan, Europe.
Now-2014 Sierra 346RETS 5er BUB
Then-2002 Keystone Springdale 286RLDS TT
Nights camped in 2014-28, 2015-127, 2016-10