Welcome to the forum!
With a good hitch set up, such as Equalizer or Reese Strait Line (aka dual cam), there would not be any problem towing a trailer in the size range you are considering as long as the weights (tongue and total) are within the ratings of your tow vehicle. Although it would tow well on the road, the longer the trailer, the more room you need to maneuver. This can be a problem if you anticipate primitive (aka "boondocking") camping or some of the national forest campgrounds where there may be tight turns and limited space. This probably will not be an issue for you as you believe you will be mostly in established campgrounds with full hookups. These types of campgrounds are well equipped to handle trailers this size and larger.
Be warned - as you are familiar with towing a fifth wheel, pull behinds will not tow as stable as a fifth wheel. They still tow very nicely, but by their nature, you will feel their input to the tow vehicle's steering/stability more than you will with a fifth wheel.
Glenn & Beth (Dad & Mom)
David & Audra (12 year old twins)
2006 Dodge Power Wagon (Adventure & Tow Vehicle)
2006 Rockwood 8281SS (Home away from Home)