We just returned from a 1047 mile trip - Northern VA to Lake George, NY and back. Here's what I would recommend for safety, comfort, and peace of mind:
1. Before you go make certain to do a safety check of your tow vehicle/trailer or motorhome so that you can be confident that you are in the best shape you can be for such a long journey. Check tire treads, tire pressures, fluid levels, lights and turn signals, etc. You can find a good video on You Tube for info or check on here for a checklist if you need to.
2. Find the closest CAT (or other) scale on your route and run your rig over it to check your weights. It only takes a few minutes and can be a life saver. It also takes some of the stress out to know that you are set up properly on such a long trip.
3. Stop every few hours (you'll have to for gas anyway
) and make sure to get out and stretch your legs. Try to find some Flying J or other RV-Friendly truck stops in advance of your trip. Stop there for gas/breaks if you can to ensure easy ingress/egress and less stress.
4. Switch drivers when you need to take a break.
5. Stop for the night if you need to or there is a fun stop along your route.
6. Have fun!!!