I think I would try this route
I used to live in Daytona Beach area and would travel out 92 out to DeLand, then over to 44 heading westbound across central FL to avoid the whole Sanford area where it seems to bottle up on I4. Been about 10 years since I've been back through that area, but I'm sure its still bad. This route might be a little longer, but I bet its less stress, which I tend to favor nowadays.
Also, if you want to avoid Daytona and break off a little further north, US40 heads west out of Ormond Beach towards Gainesville. And coming south down I95 into FL, may want to look into US301 or 17/19 across central Florida. Link to that route