I just went that route a couple of weeks ago going down to visit the mouse.
Northbound through Atlanta, take the bypass!!! Tons of construction on the northbound side. And as others said, take the west bound side, think the sign says Birmingham. The east side has what the call spaghetti junction, no fun in a car, wouldn't even think of it in an RV if I could avoid it.
Going south, I stayed on 75 and went downtown, it really wasn't that bad. I was pulling our TT and didn't have any problems, just have to pay attention to what lane you are in for the next exit. I spent most of the time in the number 2 or 3 lane.
The rest of the route is uneventful. Set the cruise and enjoy the scenery.
2015 32 Foot Rockwood 8289WS 5th Wheel
2013 Chevy 3/4 Ton TV