Northern Missouri is pretty wide. East or West? Either way, you'll probably go up thru Memphis and into Mo on, I55. Not many options going thru Arkansas. I55 or come up thru Little Rock and go up on Hwy 65 into Branson and on to Springfield and on from there. Hwy 65 is hilly and curvey, but there is lots of MH and RV traffic coming up going to Branson. I work in Harrison, AR. Just south of Branson a ways. Small town but when the season starts we have our own version of bumper to bumper traffic. Luckily it's only about a mile or so. But can make it tough to go to lunch sometimes.
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2011 Ford F250 6.2L gasser
2005 WildCat WCF28RK