Oswego - that's the route we take 4 times a year from Oswego, NY to Ft. Myers Beach FL. Be aware that you will encounter a lot of truck traffic (they don't like I-95 either) and some substantial hills along this route. Take your time and enjoy the scenery, it's definitely less stressful than dealing with Richmond, Baltimore and Washington DC. For my 1500 mile trip, the 81/77/26/95 route is 100 miles further, but I think it's faster. The other obvious caution - watch the weather and change your plans accordingly even if you have to take I-95 to avoid big storms.
2015 Rockwood Ultra Lite 2604 WS. Rear LR, large street side slide with small wardrobe slide in BR.
2014 Ram 1500 Eco Diesel Laramie Quad Cab.