Obviously not a universal statement as I just went back to a travel trailer from a fifth wheel. I am very pleased with the transition. The towing dynamics going forward are different but not black/white as described in other posts. Where there is a big difference when hooked to your tow vehicle, is when backing up. The TT responds much quicker and is easier to position on a dime as opposed to backing a fifth wheel. I like the idea of not having a heavy hitch in the bed of the truck, using the extra space in the bed of truck for storage, everything on one level in the TT and the need for a 1/2 ton versus a 3/4 ton or bigger for a fifth wheel. Typically, for the same features, fifth wheels are more expensive to purchase than TT.
Like all other comments here, these are just my opinions. Remember, opinions are very subjective as we, by human nature, need to justify our decisions.