I'm running Yokohama 15" A/T tires and have had NO problems since the switch.
My 228 came with 175x80-13, dealer did a 4.5" lift and installed 205x75-14 ST tires. The lift helped, but in the first few months I went through three tires due to the rock and ledges I was pulling the trailer up while living in Moab.
So, there was enough room to install larger tires, so I purchased some 15" rims and the local tire store ordered and installed a set of 215x70-15 Yokohama A/T-S tires and have never had a problem. They are NOT D-rate, and don't believe D-rated are required for a small trailer like the Mac, so long as you get a good load rating. The sharp rocks of the Moab area did not cause any problems with them.
And when I lived in Moab, and I had a Hummer, I took that popup to places I probably should not have. I have also taken the trailer down some nasty l roads to disperse in the middle of nowhere with the pickup.
If you are going larger, then there should be no problems. Just keep an eye on the load rating of the tires.
My original tires had a load rating of 1360 each. So I had to make sure my non-ST tires met that spec, or surpassed it. The dealer installed the ST 14" tires and they had a load rating of 1760. The 15" tires I installed have a load rating of 1653. That gave me a 293 lbs rating OVER the ST tires that came from the factory.
Diameter of the tires went from 24" for the 13" to 26.9" for the 15" tires. So that gave me just short of 1.5" of extra ground clearance, but still gave me plenty of room between the top of the tire and the wheel well.
The rims I got online at Shadow trailers; purchased two aluminum for the trailer and to save some money, one steel for the spare. The spare is the same size and brand.
Last year, I did have to replace all the springs due to the areas I pulled the trailer into caused the bottom spring leaf to crack. So I replaced them with a heavier springs and increased the length of the rear shackle by about an inch (also replaced the brakes too, but didn't need to just wanted auto adjusting brakes).
The tires track as good, if not better than the ST tires, they are wearing perfect even, just checked them the other day getting ready for the first trip back to Moab. I'll guess 10K miles and no punctures, no problems.