I use the Andersen Ultimate on my 2015 GMC 2500 which has a 6.6ft bed. I added a Curt Extenda Ball to move my Andersen 4" toward the tailgate. Basically, the Extenda Ball replaces the flip-over ball that comes with the truck's goose hitch.
I don't know what size your F250 bed is since it could be anywhere from 5.5ft to 6.7 feet so suggest you measure. If you want to see what I did, I posted a very amateur video I did a couple of years ago that might answer some of your questions.
Here's my video I did to explain it.
Andersen Reverse Mount explained