I drove both before finalizing my decision. I honestly didn't think the 2500 ride was so much better that I would be willing to sacrifice the payload of the 3500. So, I went 3500. It's basically even money one way or the other. I did notice that some things are standard on the 3500 that aren't on the 2500 (limited slip diff if I recall), so, the MSRP is very close once you get apples to apples.
The 3500 is definitely rougher on the road than any of my 1/2 ton trucks in the past, but, that's the price to pay for wanting to be able to tow a house wherever we go.