I did see this once at a CG in MS where a guy was turning while cresting a small hill. Popped his rails right out, but fortunately no damage to the truck. One rail was bent though. I would say it's a good idea to remove the rails and avoid the issue altogether. Amazon sells several varieties of stake hole plugs and covers to enhance the look of the truck for a very reasonable price.
"Walk softly...and carry a lot of tools!
2016 Ford F250 Super Duty Crew Cab, 4x4
2021 Palomino Puma 27RLSS