Fast and easy is to go on up 191 to I-40 and over to Grand Junction then head on down to Montrose that way.
Going to Monticello then east on 491 and then north on 141 will take you into some winding roads with a lot of steep grades up and down. It can be done but it's the middle of nowhere and services are far between.
2016 RAM 1500 - 2016 Keystone Laredo 265SRK
The road goes on forever and the party never ends.