don't see why not, if you're staying on the coast.
only areas i wouldn't take a MH are on parts of Highway 1: from Hearst Castle to Carmel, from north of the Golden Gate Bridge to Bodega Bay and from Fort Bragg to Leggett.
unless you have a short MH.
Highway 101 will be fine for any length of MH.
Dan-Retired California Firefighter/EMT
and Zoe the Wonder Dog(R.I.P.)
2016 PrimeTime TracerAIR 255, pushing a 2014 Ford F150 SCREW XTR 4x4 3.5 Ecoboost w/Max Tow Package