@EricNJ, my conclusion from all the input from posts and Youtube videologs are, probably best not to do it. Sections of the loop have steep inclines, and some hairpin turns.
All kidding aside, if you do drive the loop probably best to at least drive counter-clockwise, that way as you encounter scenic turnouts along the highway you don't have to make a left-turn against oncoming traffic.
If you just take the toad, you could probably do the loop in one day, but it would be rushed and a long day. Why not find a nice safe RV park in Baddeck for the week, and leave the coach locked up overnight while you make the loop in the toad and book a B&B somewhere half-way? Might be a whole lot less stressful.
I don't have an RV and toad, but rather a 19' truck with a 22' trailer, so I would face the same long-rig concerns. The above is my plan for next year.
All that said, there are a number of Youtube videologs posted with good dashcam shots of the road at different sections of the loop, and some campground photos.
search this for example
https://www.google.com/search?q=yout...hrome&ie=UTF-8
Have fun and I look forward to a full report when you return