https://www.attractionsofamerica.com/states-map.php
Click on the link above to give you an overview of things to see in the states you plan to visit if you know which ones now. My DW and I are doing a cross-country trip, leaving from Buffalo, NY in May and we have used that website to highlight some attractions in states we will be going through.
The term "The Great Lakes" is very broad in definition. One trip I could suggest is going up the East coast of Wisconsin along Lake Michigan, crossing over in the UP of Michigan, touring the UP, and then working your way down the West coast of Michigan which in my opinion they do New England better than New England. Plan your stops by how many miles you want to drive each day and you can not go wrong with where ever you stop. From there you could drop down to I90 and follow the contours of Lake Erie through Ohio where there would be numerous places to stop, i.e. Cleveland and the Rock & Roll HOF, Cedar Point, and so on. You could continue along 90 through Pennsylvania, stopping in Erie, a great small city, into New York and stopping in Buffalo and Canalside, continue on I 190 to Niagara Falls, and from there NYS Rt. 104 or 18 that follows Lake Ontario and stop off in Rochester, NY and visit the Genessee Brewing company and the Eastman Kodak Museum and learn the history of photography. Follow 104 or drop down again to I90 to I81 in Syracuse and go North to the 1000 Islands Region in Clayton and Alexander Bay and the St. Lawrence Seaway and watch the world of freighters traveling through the locks in Messina, NY on their way to the Atlantic Ocean.
As I said, The Great Lakes is a vast and broad area to visit. Enjoy your trip and good luck in your plans.
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