In the past i could tell a difference going from 16s to 18s, but i couldn't tell going from 18s to 20s. And i noticed going from 20s on one tahoe to 22s on another, the 22s seemed rougher.
Butttttt...... every brand and style of tire is different and rides different so its hard to speculate.
I know about 12 years ago i bought my first crew cab Chevy and i thought it rode like a Cadillac and a dream compared to my extended cab that was only a year old. (Both 4x4) My mother rode with me after i got it and said " it sure rides like a truck", but she had, and still has a Mercury Grand Marquis, and those cars feel like their floating.
Just drive a few and try them out and see what you like.
Fyi-- if a gm heavy duty is "leveled", it will often times ride a little rougher as well.