I check the tire pressure before every trip, and visually inspect the tires at every stop. Since the tires are rated for 75 MPH, I try not to go faster than 70 MPH. After bringing the trailer home from the dealer and before taking our first trip, I took the tires to get balanced at Discount Tires. This is how much lead they needed:
As you can see those tires were bouncing all over the place, but we did not feel anything inside the truck. I am pretty sure blowouts were just around the corner. IMHO, balancing the tires is just as important as checking tire pressure, load and speed ratings, etc.