Other than not being sealed as all ready discussed the only other problem that I can see is with large (heavy) type slides. If you read the instructions for most slides it will say that the RV should be level and preferably with the jacks down before slide operation.
I see no problem with operating a small slide to gain access to the bathroom or such, but I would not recommend operating a large heavy slide while on the road unless you are assured that you are level.
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Chuck & Sandra
Engineer/Teacher
2010 F350 CC 6.4
2015 Prime Time Sanibel 3601
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